A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients.

ABSTRACT: Although O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation status is an important marker for glioblastoma multiforme (GBM), there is considerable variability in the clinical outcome of patients with similar methylation profiles. The present study aimed to refine the prognostic and predictive value of MGMT promoter status in GBM by identifying a micro (mi)RNA risk signature. Data from The Cancer Genome Atlas was used for this study, with MGMT promoter-methylated samples randomly divided into training and internal validation sets. Data from The Chinese Glioma Genome Atlas was used for independent validation. A five miRNA-based risk signature was established for MGMT promoter-methylated GBM to distinguish cases as high- or low-risk with distinct prognoses, which was confirm

SUBMITTER: Cheng W 

PROVIDER: S-EPMC4745726 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature