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MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN.

ABSTRACT: MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and invasion in vitro. We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN.

SUBMITTER: Yu T

PROVIDER: S-EPMC4745794 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN.

Yu Tao T Liu Lei L Li Jing J Yan Mingxia M Lin Hechun H Liu Ying Y Chu Dandan D Tu Hong H Gu Aiqin A Yao Ming M

Oncotarget 20151001 30

MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and in ...[more]

PMID: 26317552

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