Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.

ABSTRACT: Most commonly originating from breast malignancies, metastatic bone cancer causes bone destruction and severe pain. Although novel chemotherapeutic agents have increased life expectancy, patients are experiencing higher incidences of fracture, pain, and drug-induced side effects; furthermore, recent findings suggest that patients are severely undertreated for their cancer pain. Strong analgesics, namely opiates, are first-line therapy in alleviating cancer-related pain despite the severe side effects, including enhanced bone destruction with sustained administration. Bone resorption is primarily treated with bisphosphonates, which are associated with highly undesirable side effects, including nephrotoxicity and osteonecrosis of the jaw. In contrast, cannabinoid receptor 2 (CB(2) ) receptor

SUBMITTER: Lozano-Ondoua AN 

PROVIDER: S-EPMC4745976 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature