Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma.

ABSTRACT:

Background

Recurrent mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, which are frequent in gliomas, result in marked accumulation of the metabolic by-product 2-hydroxyglutarate (2-HG) within tumors. In other malignancies, such as acute myeloid leukemia, presence of IDH mutation is associated with elevated 2-HG levels in serum or urine compartments. Circulating 2-HG in patients with glial malignancies has not been thoroughly investigated.

Methods

In this study, we analyzed 2-HG levels in the serum and urine of a large set of patients with IDH-mutant and IDH-wild-type glioma, and the cerebrospinal fluid (CSF) from a subset of this cohort.

Results

We found that 2-HG was elevated in the urine of patients with IDH-mutant versus IDH-wild-type glioma, alth

SUBMITTER: Fathi AT 

PROVIDER: S-EPMC4746092 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature