One-Pot Catalytic Asymmetric Synthesis of Tetrahydrocarbazoles.

ABSTRACT: A one-pot asymmetric synthesis of 1,2,3,4-tetrahydrocarbazoles has been developed via an enantioselective [3 + 3] annulation of 2-alkynylindoles and donor-acceptor cyclopropanes. In the presence of chiral Lewis acids as catalysts, a series of optically active tetrahydrocarbazoles were furnished in high yields (63-87%) with good to excellent levels of enantioselectivity (up to 94% ee).

SUBMITTER: Liu QJ 

PROVIDER: S-EPMC4746102 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature