Ontology highlight
ABSTRACT:
SUBMITTER: Schick UM
PROVIDER: S-EPMC4746331 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
American journal of human genetics 20160121 2
Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for admixture and family relationships. We discovered and replicated associations with five genes (ACTN1, ETV7, GABBR1-MOG, MEF2C, and ZBTB9-BAK1). Our strongest association was with Amerindian-specific variant rs117672662 (p value = 1.16 × 10(-28)) i ...[more]