Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.

ABSTRACT: The bovine lungworm, Dictyocaulus viviparus (order Strongylida), is an important parasite of livestock that causes substantial economic and production losses worldwide. Here we report the draft genome, variome, and developmental transcriptome of D. viviparus. The genome (161 Mb) is smaller than those of related bursate nematodes and encodes fewer proteins (14,171 total). In the first genome-wide assessment of genomic variation in any parasitic nematode, we found a high degree of sequence variability in proteins predicted to be involved host-parasite interactions. Next, we used extensive RNA sequence data to track gene transcription across the life cycle of D. viviparus, and identified genes that might be important in nematode development and parasitism. Finally, we predicted genes that cou

SUBMITTER: McNulty SN 

PROVIDER: S-EPMC4746573 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature