The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin.

ABSTRACT: Differentiation of inflammatory macrophages from monocytes is characterized by an orderly integration of epigenetic and transcriptional regulatory mechanisms guided by lineage-determining transcription factors such as PU.1. Further activation of macrophages leads to a stimulus- or microenvironment-specific signal integration with subsequent transcriptional control established by the action of tissue- or signal-associated transcription factors. Here, we assess four histone modifications during human macrophage activation and integrate this information with the gene expression data from 28 different macrophage activation conditions in combination with GM-CSF. Bioinformatically, for inflammatory macrophages we define a unique network of transcriptional and epigenetic regulators (TRs), which w

SUBMITTER: Schmidt SV 

PROVIDER: S-EPMC4746609 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature