Genome stability of Propionibacterium acnes: a comprehensive study of indels and homopolymeric tracts.

ABSTRACT: We present a species-wide comparative analysis of 90 genomes of Propionibacterium acnes that represent the known diversity of the species. Our results are augmented by six high-quality genomes and a manual investigation of all gene-sized indels found in the strains. Overall, the order of genes is conserved throughout the species. A public sybil database for easy comparative analysis of the 90 genomes was established. The analysis of indels revealed a total of 66 loci of non-core genes that correlate with phylogenetic clades. No gene was strain-specific in agreement with our conclusion that the P. acnes pan-genome is closed. An exhaustive search for homopolymeric tracts (HPTs) identified a total of 54 variable-length HPTs almost exclusively of guanine/cytosines located between genes or affe

SUBMITTER: Scholz CF 

PROVIDER: S-EPMC4746626 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature