Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4746670 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Wang Xianlong X Cao Chunwei C Huang Jiaojiao J Yao Jing J Hai Tang T Zheng Qiantao Q Wang Xiao X Zhang Hongyong H Qin Guosong G Cheng Jinbo J Wang Yanfang Y Yuan Zengqiang Z Zhou Qi Q Wang Hongmei H Zhao Jianguo J
Scientific reports 20160209
Pig shows multiple superior characteristics in anatomy, physiology, and genome that have made this species to be more suitable models for human diseases, especially for neurodegenerative diseases, because they have similar cerebral convolutions compared with human neocortex. Recently, CRISPR/Cas9 system shows enormous potential for engineering the pig genome. In this study, we expect to generate human Parkinson's disease pig model using CRISPR/Cas9 system by simultaneously targeting three distin ...[more]