Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex.

ABSTRACT:

Background

Novel taste memories, critical for animal survival, are consolidated to form long term memories which are dependent on translation regulation in the gustatory cortex (GC) hours following acquisition. However, the role of transcription regulation in the process is unknown.

Results

Here, we report that transcription in the GC is necessary for taste learning in rats, and that drinking and its consequences, as well as the novel taste experience, affect transcription in the GC during taste memory consolidation. We show differential effects of learning on temporal dynamics in set of genes in the GC, including Arc/Arg3.1, known to regulate the homeostasis of excitatory synapses.

Conclusions

We demonstrate that in taste learning, transcription programs were activat

SUBMITTER: Inberg S 

PROVIDER: S-EPMC4746785 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature