Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22;q14).

ABSTRACT:

Background

Myolipoma of soft tissue is an extremely rare benign tumor composed of mature adipose tissue and smooth muscle cells. It is found predominantly in women. The cytogenetic and molecular genetic features of myolipomas remain largely unexplored. Here we present the first cytogenetically analyzed myolipoma.

Methods

Cytogenetic and molecular genetic analyses were done on a myolipoma.

Results

G-banding analysis of short-term cultured cells from the myolipoma yielded a karyotype with a single clonal chromosome abnormality: 46,XX,t(9;12)(p22;q14). Fluorescence in situ hybridization experiments demonstrated that HMGA2 (in 12q14) was rearranged. Molecular genetic analysis showed that the translocation resulted in fusion of HMGA2 with the C9orf92 gene (from 9p22). The

SUBMITTER: Panagopoulos I 

PROVIDER: S-EPMC4746792 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature