Scalable linkage-disequilibrium-based selective sweep detection: a performance guide.

ABSTRACT:

Background

Linkage disequilibrium is defined as the non-random associations of alleles at different loci, and it occurs when genotypes at the two loci depend on each other. The model of genetic hitchhiking predicts that strong positive selection affects the patterns of linkage disequilibrium around the site of a beneficial allele, resulting in specific motifs of correlation between neutral polymorphisms that surround the fixed beneficial allele. Increased levels of linkage disequilibrium are observed on the same side of a beneficial allele, and diminish between sites on different sides of a beneficial mutation. This specific pattern of linkage disequilibrium occurs more frequently when positive selection has acted on the population rather than under various neutral models. Thus, de

SUBMITTER: Alachiotis N 

PROVIDER: S-EPMC4746822 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature