Effect and Safety of Rosuvastatin in Acute Ischemic Stroke.

ABSTRACT:

Background and purpose

The benefit of statins in acute stroke remains uncertain. Statins may prevent stroke recurrence during the acute stage of stroke via pleiotropic effects. However, statins may increase the risk of intracerebral hemorrhage. We investigated the effect and safety of rosuvastatin in acute stroke patients.

Methods

This randomized, double-blind, multi-center trial compared rosuvastatin 20 mg and placebo in statin-naïve stroke patients who underwent diffusion-weighted imaging (DWI) within 48 hours after symptom onset. The primary outcome was occurrence of new ischemic lesions on DWI at 5 or 14 days.

Results

This trial was stopped early after randomization of 316 patients due to slow enrollment. Among 289 patients with at least one follow-up imaging, the

SUBMITTER: Heo JH 

PROVIDER: S-EPMC4747071 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature