Ontology highlight
ABSTRACT:
SUBMITTER: Alarcon C
PROVIDER: S-EPMC4747460 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Alarcon Cristina C Boland Brandon B BB Uchizono Yuji Y Moore Patrick C PC Peterson Bryan B Rajan Suryalekha S Rhodes Olivia S OS Noske Andrew B AB Haataja Leena L Arvan Peter P Marsh Bradly J BJ Austin Jotham J Rhodes Christopher J CJ
Diabetes 20150825 2
Pancreatic β-cells normally produce adequate insulin to control glucose homeostasis, but in obesity-related diabetes, there is a presumed deficit in insulin production and secretory capacity. In this study, insulin production was assessed directly in obese diabetic mouse models, and proinsulin biosynthesis was found to be contrastingly increased, coupled with a significant expansion of the rough endoplasmic reticulum (without endoplasmic reticulum stress) and Golgi apparatus, increased vesicular ...[more]