Transcriptomics Modeling of the Late-Gestation Fetal Pituitary Response to Transient Hypoxia.

ABSTRACT:

Background

The late-gestation fetal sheep responds to hypoxia with physiological, neuroendocrine, and cellular responses that aid in fetal survival. The response of the fetus to hypoxia represents a coordinated effort to maximize oxygen transfer from the mother and minimize wasteful oxygen consumption by the fetus. While there have been many studies aimed at investigating the coordinated physiological and endocrine responses to hypoxia, and while immunohistochemical or in situ hybridization studies have revealed pathways supporting the endocrine function of the pituitary, there is little known about the coordinated cellular response of the pituitary to the hypoxia.

Results

Thirty min hypoxia (from 17.0±1.7 to 8.0±0.8 mm Hg, followed by 30 min normoxia) upregulated 595 and do

SUBMITTER: Wood CE 

PROVIDER: S-EPMC4747542 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature