Polymorphisms in HLA Class II Genes Are Associated With Susceptibility to Staphylococcus aureus Infection in a White Population.

ABSTRACT:

Background

Staphylococcus aureus can cause life-threatening infections. Human susceptibility to S. aureus infection may be influenced by host genetic variation.

Methods

A genome-wide association study (GWAS) in a large health plan-based cohort included biologic specimens from 4701 culture-confirmed S. aureus cases and 45 344 matched controls; 584 535 single-nucleotide polymorphisms (SNPs) were genotyped on an array specific to individuals of European ancestry. Coverage was increased by imputation of >25 million common SNPs, using the 1000 Genomes Reference panel. In addition, human leukocyte antigen (HLA) serotypes were also imputed.

Results

Logistic regression analysis, performed under the assumption of an additive genetic model, revealed several imputed SNPs (eg, rs

SUBMITTER: DeLorenze GN 

PROVIDER: S-EPMC4747615 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature