Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control.

ABSTRACT: T-lymphocyte development branches off from other lymphoid developmental programs through its requirement for sustained environmental signals through the Notch pathway. In the thymus, Notch signaling induces a succession of T-lineage regulatory factors that collectively create the T-cell identity through distinct steps. This process involves both the staged activation of T-cell identity genes and the staged repression of progenitor-cell-inherited regulatory genes once their roles in self-renewal and population expansion are no longer needed. With the recent characterization of innate lymphoid cells (ILCs) that share transcriptional regulation programs extensively with T-cell subsets, T-cell identity can increasingly be seen as defined in modular terms, as the processes selecting and actuati

SUBMITTER: Rothenberg EV 

PROVIDER: S-EPMC4747653 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature