Blood protein concentrations in the first two postnatal weeks associated with early postnatal blood gas derangements among infants born before the 28th week of gestation. The ELGAN Study.

ABSTRACT:

Aim

To explore the relationships between blood gas derangements and blood concentrations of inflammation-related proteins shortly after preterm birth.

Design

Observational cohort.

Setting

Fourteen neonatal intensive care units.

Subjects

Seven hundred and forty five infants born before the 28th week of gestation who were classified by their blood gas derangements during the first three postnatal days and by the concentrations of 25 proteins in their blood on days 1, 7, and 14. We classified these newborns by whether or not they had a highest or lowest PaO2, PCO2, and lowest pH in the most extreme quartile, and by whether or not they had a protein concentration in the highest quartile.

Results

Blood gas derangements on two days were much more likely to be

SUBMITTER: Leviton A 

PROVIDER: S-EPMC4747654 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature