Spatial-temporal patterns of electrocorticographic spectral changes during midazolam sedation.

ABSTRACT:

Objective

To better understand 'when' and 'where' wideband electrophysiological signals are altered by sedation.

Methods

We generated animation movies showing electrocorticography (ECoG) amplitudes at eight spectral frequency bands across 1.0-116 Hz, every 0.1s, on three-dimensional surface images of 10 children who underwent epilepsy surgery. We measured the onset, intensity, and variance of each band amplitude change at given nonepileptic regions separately from those at affected regions. We also determined the presence of differential ECoG changes depending on the brain anatomy.

Results

Within 20s following injection of midazolam, beta (16-31.5 Hz) and sigma (12-15.5 Hz) activities began to be multifocally augmented with increased variance in amplitude at each site

SUBMITTER: Nishida M 

PROVIDER: S-EPMC4747792 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature