The Presence of Oxalobacter formigenes in the Microbiome of Healthy Young Adults.

ABSTRACT:

Purpose

Oxalobacter formigenes, a member of the human colonic microbiota with a major role in net colonic oxalate transport and secretion, is protective against the formation of calcium oxalate kidney stones. We describe the prevalence, relative abundance and stability of O. formigenes in healthy young adults in the United States.

Materials and methods

We used HMP (Human Microbiome Project) data on fecal samples from 242 healthy young adults who had 1 to 3 study visits. Samples underwent whole genomic shotgun sequencing and/or 16S rRNA sequencing. Three data sets available from the processed sequence data were studied, including whole genomic shotgun metagenomic analysis by alignment to reference genomes using shotgun community profiling, or MetaPhlAn (http://huttenhower.sph

SUBMITTER: Barnett C 

PROVIDER: S-EPMC4747808 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature