Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer.

ABSTRACT:

Background

High-level physical activity is associated with lower colorectal cancer (CRC) mortality, likely through insulin sensitization. Insulin receptor substrate 1 (IRS1) is a mediator of insulin and insulin-like growth factor (IGF) signaling pathways, and its down-regulation is associated with insulin resistance. Therefore, we hypothesized that tumor IRS1 expression status might modify cellular sensitivity to insulin and IGF, and the prognostic association of physical activity.

Methods

We assessed IRS1 expression level in 371 stage I-III rectal and colon cancers in the Nurses' Health Study and the Health Professionals Follow-up Study by immunohistochemistry. In survival analysis, Cox proportional hazards model was used to assess an interaction between post-diagnosis phys

SUBMITTER: Hanyuda A 

PROVIDER: S-EPMC4747829 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature