MiR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival.

ABSTRACT:

Rationale

In Drosophila, the Hippo signaling pathway negatively regulates organ size by suppressing cell proliferation and survival through the inhibition of Yorkie, a transcriptional cofactor. Yes-associated protein (YAP), the mammalian homolog of Yorkie, promotes cardiomyocyte growth and survival in postnatal hearts. However, the underlying mechanism responsible for the beneficial effect of YAP in cardiomyocytes remains unclear.

Objectives

We investigated whether miR-206, a microRNA known to promote hypertrophy in skeletal muscle, mediates the effect of YAP on promotion of survival and hypertrophy in cardiomyocytes.

Methods and results

Microarray analysis indicated that YAP increased miR-206 expression in cardiomyocytes. Increased miR-206 expression induced cardiac

SUBMITTER: Yang Y 

PROVIDER: S-EPMC4747867 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature