Quorum Sensing: An Under-Explored Phenomenon in the Phylum Actinobacteria.

ABSTRACT: Quorum sensing is known to play a major role in the regulation of secondary metabolite production, especially, antibiotics, and morphogenesis in the phylum Actinobacteria. Although it is one of the largest bacterial phylum, only 25 of the 342 genera have been reported to use quorum sensing. Of these, only nine have accompanying experimental evidence; the rest are only known through bioinformatic analysis of gene/genome sequences. It is evident that this important communication mechanism is not extensively explored in Actinobacteria. In this review, we summarize the different quorum sensing systems while identifying the limitations of the existing screening strategies and addressing the improvements that have taken place in this field in recent years. The γ-butyrolactone system turned out t

SUBMITTER: Polkade AV 

PROVIDER: S-EPMC4748050 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature