Immunologic response in treatment-naive HIV-2-infected patients: the IeDEA West Africa cohort.

ABSTRACT:

Introduction

Response to antiretroviral therapy (ART) among individuals infected with HIV-2 is poorly described. We compared the immunological response among patients treated with three nucleoside reverse-transcriptase inhibitors (NRTIs) to boosted protease inhibitor (PI) and unboosted PI-based regimens in West Africa.

Methods

This prospective cohort study enrolled treatment-naïve HIV-2-infected patients within the International Epidemiological Databases to Evaluate AIDS collaboration in West Africa. We used mixed models to compare the CD4 count response to treatment over 12 months between regimens.

Results

Of 422 HIV-2-infected patients, 285 (67.5%) were treated with a boosted PI-based regimen, 104 (24.6%) with an unboosted PI-based regimen and 33 (7.8%) with three N

SUBMITTER: Balestre E 

PROVIDER: S-EPMC4748109 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature