Ontology highlight
ABSTRACT:
SUBMITTER: Nakagawa A
PROVIDER: S-EPMC4748248 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160205
Opiates such as morphine and codeine are mainly obtained by extraction from opium poppies. Fermentative opiate production in microbes has also been investigated, and complete biosynthesis of opiates from a simple carbon source has recently been accomplished in yeast. Here we demonstrate that Escherichia coli serves as an efficient, robust and flexible platform for total opiate synthesis. Thebaine, the most important raw material in opioid preparations, is produced by stepwise culture of four eng ...[more]