Effects of BDNF polymorphism and physical activity on episodic memory in the elderly: a cross sectional study.

ABSTRACT:

Background

The brain-derived neurotrophic factor (BDNF) concentration is highest in the hippocampus compared with that in other brain structures and affects episodic memory, a cognitive function that is impaired in older adults. According to the neurotrophic hypothesis, BDNF released during physical activity enhances brain plasticity and consequently brain health. However, even if the physical activity level is involved in the secretion of neurotrophin, this protein is also under the control of a specific gene. The aim of the present study was to examine the effect of the interaction between physical activity and BDNF Val66Met (rs6265), a genetic polymorphism, on episodic memory.

Methods

Two hundred and five volunteers aged 55 and older with a Mini Mental State Examination s

SUBMITTER: Canivet A 

PROVIDER: S-EPMC4748321 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature