CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease.

ABSTRACT: The immune response is highly active in Alzheimer's disease (AD). Identification of genetic risk contributed by immune genes to AD may provide essential insight for the prognosis, diagnosis, and treatment of this neurodegenerative disease. In this study, we performed a genetic screening for AD-related top immune genes identified in Europeans in a Chinese cohort, followed by a multiple-stage study focusing on Complement Factor H (CFH) gene. Effects of the risk SNPs on AD-related neuroimaging endophenotypes were evaluated through magnetic resonance imaging scan, and the effects on AD cerebrospinal fluid biomarkers (CSF) and CFH expression changes were measured in aged and AD brain tissues and AD cellular models. Our results showed that the AD-associated top immune genes reported in Europeans

SUBMITTER: Zhang DF 

PROVIDER: S-EPMC4748428 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature