What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme.

ABSTRACT:

Background

MicroRNAs (miRNAs) are short non-protein-coding RNA species that have a regulatory function in modulating protein translation and degradation of specific mRNAs. MicroRNAs are estimated to target approximately 60% of all human mRNAs and are associated with the regulation of all physiological processes. Similar to many messenger RNAs (mRNA), miRNAs exhibit marked tissue specificity, and appear to be dysregulated in response to specific pathological conditions. Perhaps, one of the most significant findings is that miRNAs are detectable in various biological fluids and are stable during routine clinical processing, paving the way for their use as novel biomarkers. Despite an increasing number of publications reporting individual miRNAs or miRNA signatures to be diagnostic of

SUBMITTER: Tonge DP 

PROVIDER: S-EPMC4748454 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature