A recombinant subunit vaccine for the control of ovine psoroptic mange (sheep scab).

ABSTRACT: Sheep scab, caused by infestation with the mite Psoroptes ovis, is highly contagious, causing intense pruritus and represents a major welfare and economic concern. Disease control strategies rely upon chemotherapy, however, sustainability is questionable due to issues of chemical residues, eco-toxicity and acaricide resistance. Control by vaccination is supported by demonstration of protective immunity in sheep previously infested with P. ovis. We identified vaccine candidates for P. ovis based on: (1) antigens selected by their interaction with host signalling pathways and the host immune-response; and (2) those shown to be either immunogenic or involved in mite feeding. This resulted in the development and validation, in repeated immunisation and challenge trials, of a seven recombinant

SUBMITTER: Burgess ST 

PROVIDER: S-EPMC4748516 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature