Ontology highlight
ABSTRACT:
SUBMITTER: Moudry P
PROVIDER: S-EPMC4748576 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
The Journal of cell biology 20160125 3
Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human cancer remain unclear. Here, through an unbiased small interfering RNA screen, we identified and validated TOPBP1 as a novel determinant whose loss sensitized human cells to olaparib, an inhibitor of poly(ADP-ribose) polymerase. We show that TOPBP1 acts in homologous recombination (HR) repair, impacts olaparib response, and exhibits aberran ...[more]