Association Between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort.

ABSTRACT:

Background

Short-term fine particulate matter (PM2.5) exposure has been linked with increased QT interval duration, a marker of ventricular repolarization and a risk factor for cardiac arrhythmia and sudden death, in several studies. Only one previous study evaluated whether long-term PM exposure is related to the QT interval. We aim to evaluate whether subchronic and long-term exposure to PM2.5 at home is linked with QT duration in an elderly cohort.

Methods

We measured heart-rate corrected QT interval duration among 404 participants from the Greater Boston area between 2003 and 2011. We modeled residential PM2.5 exposures using a hybrid satellite- and land use-based model. We evaluated associations between moving averages of short-term (1-2 days), subchronic (3-28 days), a

SUBMITTER: Mordukhovich I 

PROVIDER: S-EPMC4748722 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature