Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip study.

ABSTRACT: Previous studies have demonstrated that macromolecular synthesis in the brain is modulated in association with the occurrence of sleep and wakefulness. Similarly, the spectral composition of electroencephalographic activity that occurs during sleep is dependent on the duration of prior wakefulness. Since this homeostatic relationship between wake and sleep is highly conserved across mammalian species, genes that are truly involved in the electroencephalographic response to sleep deprivation might be expected to be conserved across mammalian species. Therefore, in the rat cerebral cortex, we have studied the effects of sleep deprivation on the expression of immediate early gene and heat shock protein mRNAs previously shown to be upregulated in the mouse brain in sleep deprivation and in rec

SUBMITTER: Terao A 

PROVIDER: S-EPMC4749022 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature