White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.

ABSTRACT:

Background and purpose

White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Methods

Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-n

SUBMITTER: Hofer E 

PROVIDER: S-EPMC4749149 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature