Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients.

ABSTRACT:

Background

Chronic inflammation is frequently observed on histological analysis of malignant and non-malignant prostate specimens. It is a suspected supporting factor for prostate diseases and their progression and a main cause of false positive PSA tests in cancer screening. We hypothesized that inflammation induces autoantibodies, which may be useful biomarkers. We aimed to identify and validate prostate inflammation associated serum autoantibodies in prostate cancer patients and evaluate the expression of corresponding autoantigens.

Methods

Radical prostatectomy specimens of prostate cancer patients (N = 70) were classified into high and low inflammation groups according to the amount of tissue infiltrating lymphocytes. The corresponding pre-surgery blood serum samples we

SUBMITTER: Schlick B 

PROVIDER: S-EPMC4749310 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature