Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex.

ABSTRACT: Previous studies have reported inconsistent effects of dietary restriction (DR) on cortical inhibition. To clarify this issue, we examined the response properties of neurons in the primary visual cortex (V1) of DR and control groups of cats using in vivo extracellular single-unit recording techniques, and assessed the synthesis of inhibitory neurotransmitter GABA in the V1 of cats from both groups using immunohistochemical and Western blot techniques. Our results showed that the response of V1 neurons to visual stimuli was significantly modified by DR, as indicated by an enhanced selectivity for stimulus orientations and motion directions, decreased visually-evoked response, lowered spontaneous activity and increased signal-to-noise ratio in DR cats relative to control cats. Further, it wa

SUBMITTER: Yang J 

PROVIDER: S-EPMC4749323 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature