Antibiotic Exposure, Infection, and the Development of Pediatric Psoriasis: A Nested Case-Control Study.

ABSTRACT:

Importance

Antibiotics disrupt human microbiota and have been associated with several pediatric autoimmune diseases. Psoriasis activity has been linked to group A streptococcal and viral infections.

Objective

To determine whether antibiotic exposure and infections are independently associated with incident psoriasis in children.

Design, setting, and participants

This nested case-control study used data from the Health Improvement Network database, a population-representative electronic health records database from the United Kingdom, from June 27, 1994, through January 15, 2013. Data were analyzed from September 17, 2014, through August 12, 2015. Children aged 1 to 15 years with newly diagnosed psoriasis (n = 845) were compared with age- and sex-matched controls (n =

SUBMITTER: Horton DB 

PROVIDER: S-EPMC4749454 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature