Induction and contribution of beta platelet-derived growth factor signalling by hepatic stellate cells to liver regeneration after partial hepatectomy in mice.

ABSTRACT:

Background & aims

Hepatic stellate cells (HSCs) activate during injury to orchestrate the liver's inflammatory and fibrogenic responses. A critical feature of HSC activation is the rapid induction of beta platelet-derived growth factor (β-PDGFR), which drives cellular fibrogenesis and proliferation; in contrast, normal liver has minimal β-PDGFR expression. While the role of β-PDGFR is well established in liver injury, its expression and contribution during liver regeneration are unknown. The aim of this study was to determine whether β-PDGFR is induced during liver regeneration following partial hepatectomy (pHx), and to define its contribution to the regenerative response.

Methods

Control mice or animals with HSC-specific β-PDGFR-depletion underwent two-thirds pHx followed

SUBMITTER: Kocabayoglu P 

PROVIDER: S-EPMC4749477 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature