Mouse Model for Protein Tyrosine Phosphatase D (<i>PTPRD</i>) Associations with Restless Leg Syndrome or Willis-Ekbom Disease and Addiction: Reduced Expression Alters Locomotion, Sleep Behaviors and Cocaine-Conditioned Place Preference.

ABSTRACT: The receptor type protein tyrosine phosphatase D (PTPRD) gene encodes a cell adhesion molecule likely to influence development and connections of addiction-, locomotion- and sleep-related brain circuits in which it is expressed. The PTPRD gene harbors genome-wide association signals in studies of restless leg syndrome (Willis-Ekbom disease [WED]/restless leg syndrome [RLS]; p < 10^-8) and addiction-related phenotypes (clusters of nearby single nucleotide polymorphisms [SNPs] with 10^-2 > p > 10^-8 associations in several reports). We now report work that seeks (a) association between PTPRD genotypes and expression of its mRNA in postmortem human brains and (b) RLS-related, addiction-related and comparison behavioral phenotype

SUBMITTER: Drgonova J 

PROVIDER: S-EPMC4749486 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature