Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like Behaviour.

ABSTRACT: In zebrafish developmentally exposed to ambient ethanol (20mM-50mM) 1-9 days post fertilization (dpf), the cortisol response to stress has been shown to be significantly attenuated in larvae, juveniles and 6 month old adults. These data are somewhat at variance with similar studies in mammals, which often show heightened stress responses. To test whether these cortisol data correlate with behavioural changes in treated animals, anxiety-like behaviour of zebrafish larvae (9dpf and 10dpf) and juveniles (23dpf) was tested in locomotor assays designed to this end. In open field tests treated animals were more exploratory, spending significantly less time at the periphery of the arena. Behavioural effects of developmental exposure to ethanol were sustained in 6-month-old adults, as judged by as

SUBMITTER: Baiamonte M 

PROVIDER: S-EPMC4749633 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature