Prolonged-release fampridine and walking and balance in MS: randomised controlled MOBILE trial.

ABSTRACT:

Background

Mobility impairment is a common disability in MS and negatively impacts patients' lives.

Objective

Evaluate the effect of prolonged-release (PR) fampridine (extended-release dalfampridine in the United States) on self-assessed walking disability, dynamic/static balance and safety in patients with MS.

Methods

MOBILE was a randomised, double-blind, exploratory, placebo-controlled trial. Patients with progressive/relapsing-remitting MS and Expanded Disability Status Scale score of 4.0-7.0 were treated with PR-fampridine or placebo twice daily for 24 weeks. Efficacy endpoints included change from baseline in the 12-item MS Walking Scale (MSWS-12), Timed Up and Go (TUG) test and Berg Balance Scale (BBS).

Results

132 patients were randomised at 24 sites in

SUBMITTER: Hupperts R 

PROVIDER: S-EPMC4749757 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature