Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome.

ABSTRACT: miR-132 and miR-212 are structurally related microRNAs that have been found to exert powerful modulatory effects within the central nervous system (CNS). Notably, these microRNAs are tandomly processed from the same noncoding transcript, and share a common seed sequence: thus it has been difficult to assess the distinct contribution of each microRNA to gene expression within the CNS. Here, we employed a combination of conditional knockout and transgenic mouse models to examine the contribution of the miR-132/-212 gene locus to learning and memory, and then to assess the distinct effects that each microRNA has on hippocampal gene expression. Using a conditional deletion approach, we show that miR-132/-212 double-knockout mice exhibit significant cognitive deficits in spatial memory, recogni

SUBMITTER: Hansen KF 

PROVIDER: S-EPMC4749831 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature