There is Diversity in Disorder-"In all Chaos there is a Cosmos, in all Disorder a Secret Order".

ABSTRACT: The protein universe consists of a continuum of structures ranging from full order to complete disorder. As the structured part of the proteome has been intensively studied, stably folded proteins are increasingly well documented and understood. However, proteins that are fully, or in large part, disordered are much less well characterized. Here we collected NMR chemical shifts in a small database for 117 protein sequences that are known to contain disorder. We demonstrate that NMR chemical shift data can be brought to bear as an exquisite judge of protein disorder at the residue level, and help in validation. With the help of secondary chemical shift analysis we demonstrate that the proteins in the database span the full spectrum of disorder, but still, largely segregate into two classes;

SUBMITTER: Nielsen JT 

PROVIDER: S-EPMC4749933 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature