Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses.

ABSTRACT:

Background

Polymorphisms in the CYP1A2 genes have the potential to affect the individual capacity to convert pre-carcinogens into carcinogens. With these comprehensive meta-analyses, we aimed to provide a quantitative assessment of the association between the published genetic association studies on CYP1A2 single nucleotide polymorphisms (SNPs) and the risk of cancer.

Methods

We searched MEDLINE, ISI Web of Science and SCOPUS bibliographic online databases and databases of genome-wide association studies (GWAS). After data extraction, we calculated Odds Ratios (ORs) and 95% confidence intervals (CIs) for the association between the retrieved CYP1A2 SNPs and cancer. Random effect model was used to calculate the pooled ORs. Begg and Egger tests, one-way sensitivity analysis we

SUBMITTER: Vukovic V 

PROVIDER: S-EPMC4750358 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature