Composition and dynamics of the respiratory tract microbiome in intubated patients.

ABSTRACT:

Background

Lower respiratory tract infection (LRTI) is a major contributor to respiratory failure requiring intubation and mechanical ventilation. LRTI also occurs during mechanical ventilation, increasing the morbidity and mortality of intubated patients. We sought to understand the dynamics of respiratory tract microbiota following intubation and the relationship between microbial community structure and infection.

Results

We enrolled a cohort of 15 subjects with respiratory failure requiring intubation and mechanical ventilation from the medical intensive care unit at an academic medical center. Oropharyngeal (OP) and deep endotracheal (ET) secretions were sampled within 24 h of intubation and every 48-72 h thereafter. Bacterial community profiling was carried out by puri

SUBMITTER: Kelly BJ 

PROVIDER: S-EPMC4750361 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature