Modulation of intrinsic brain activity by electroconvulsive therapy in major depression.

ABSTRACT:

Introduction

One of the most effective interventions for intractable major depressive episodes is electroconvulsive therapy (ECT). Because ECT is also relatively fast-acting, longitudinal study of its neurobiological effects offers critical insight into the mechanisms underlying depression and antidepressant response. Here we assessed modulation of intrinsic brain activity in corticolimbic networks associated with ECT and clinical response.

Methods

We measured resting-state functional connectivity (RSFC) in patients with treatment-resistant depression (n=30), using functional magnetic resonance imaging (fMRI) acquired before and after completing a treatment series with right-unilateral ECT. Using independent component analysis, we assessed changes in RSFC with 1) symptom imp

SUBMITTER: Leaver AM 

PROVIDER: S-EPMC4750490 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature