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Selective Aromatic C-H Hydroxylation Enabled by η⁶-Coordination to Iridium(III).

ABSTRACT: We report an aromatic C-H hydroxylation protocol in which the arene is activated through η⁶-coordination to an iridium(III) complex. η⁶-Coordination of the arene increases its electrophilicity and allows for high positional selectivity of hydroxylation at the site of least electron density. Through investigation of intermediate η⁵-cyclohexadienyl adducts and arene exchange reactions, we evaluate incorporation of arene π-activation into a catalytic cycle for C-H functionalization.

SUBMITTER: D'Amato EM

PROVIDER: S-EPMC4750501 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Selective Aromatic C-H Hydroxylation Enabled by η⁶-Coordination to Iridium(III).

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Dataset Information

Selective Aromatic C-H Hydroxylation Enabled by η6-Coordination to Iridium(III).

OmicsDI is part of the ELIXIR infrastructure

Tweets

Selective Aromatic C-H Hydroxylation Enabled by η⁶-Coordination to Iridium(III).