Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer.

ABSTRACT: We aimed to identify a novel prognostic biomarker related to recurrence in stage II and III colorectal cancer (CRC) patients. Stage II and III CRC tissue mRNA expression was profiled using an Affymetrix Gene Chip, and copy number profiles of 125 patients were generated using an Affymetrix 250K Sty array. Genes showing both upregulated expression and copy number gains in cases involving recurrence were extracted as candidate biomarkers. The protein expression of the candidate gene was assessed using immunohistochemical staining of tissue from 161 patients. The relationship between protein expression and clinicopathological features was also examined. We identified 9 candidate genes related to recurrence of stage II and III CRC, whose mRNA expression was significantly higher in CRC than in n

SUBMITTER: Masuda T 

PROVIDER: S-EPMC4750537 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature