Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.

ABSTRACT:

Background

Functional deficiency of mannose-binding lectin (MBL) may contribute to the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that specific MBL2 gene polymorphisms and circulating MBL protein levels are associated with clinically relevant outcomes in the Predicting Outcome using systemic Markers In Severe Exacerbations of COPD PROMISE-COPD cohort.

Methods

We followed 277 patients with stable COPD GOLD stage II-IV COPD over a median period of 733 days (IQR 641-767) taking survival as the primary outcome parameter. Patients were dichotomized as frequent (≥ 2 AECOPD/year) or infrequent exacerbators. Serum MBL levels and single nucleotide polymorphisms of the MBL2 gene were assessed at baseline.

Results

The MBL2-HYPD haplotype was significa

SUBMITTER: Mandal J 

PROVIDER: S-EPMC4750539 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature