Maternal C-Reactive Protein Concentration in Early Pregnancy and Child Autistic Traits in the General Population.

ABSTRACT:

Background

Exposure to elevated levels of inflammatory markers during pregnancy has been suggested as possible aetiologic factor in the occurrence of autism spectrum disorder (ASD). In this study, we investigated the prospective relation between maternal C-reactive protein (CRP) during early pregnancy and children's autistic traits in the general population.

Methods

In a large population-based cohort in the Netherlands, we measured maternal CRP levels before 18 weeks of gestation (N = 4165). Parents reported on their children's autistic traits at age 6 years using the Social Responsiveness Scale, and the Pervasive Developmental Problem scale. Regression models were used to examine the relation between maternal CRP levels and autistic traits in children.

Results

Compar

SUBMITTER: Koks N 

PROVIDER: S-EPMC4751036 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature